The Impact of Environmental Factors on Neurological Health: A Synthesis of Current Evidence

DOI: 10.5281/zenodo.16059292

ABSTRACT

This podcast delves into the critical and escalating concern of environmental factors affecting neurological health. It explores a wide array of external, non-genetic influences, from ubiquitous air pollutants like PM2.5 and NO2, and various chemical neurotoxicants including pesticides and industrial chemicals, to the pervasive threat of heavy metals such as lead and mercury. The discussion also covers the direct and indirect neurological impacts of climate change, including temperature extremes and worsening air quality, as well as the effects of noise pollution. The podcast synthesizes current knowledge on how these factors contribute to neurodevelopmental disorders, cognitive decline, neurodegenerative diseases, and mental health conditions. It further explains common mechanisms of neurotoxicity like oxidative stress, neuroinflammation, and blood-brain barrier disruption. Finally, it highlights the heightened vulnerability during critical developmental windows and aging, underscores the role of genetic predispositions and socioeconomic disparities, and outlines future research directions and public health recommendations for mitigating these environmental threats to brain health.

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OBJECTIVES

1. How does the environment affect neurological health?

2. What specific environmental factors are linked to neurological problems?

3. What are the main ways environmental factors damage the nervous system?

4. Who is most vulnerable to environmental impacts on neurological health?

5. What are the main challenges in understanding the link between environment and neurological health?

6. How is research addressing these challenges?

7. What policy and public health actions are recommended to protect neurological health from environmental factors?

8. Why is a comprehensive approach necessary to safeguard neurological health?

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