Exploring Remote Neurostimulation in Multiple Sclerosis: A Conversation with Drs. Charvet and Pilloni

In this episode of the Neurostimulation Podcast, Dr. Michael Passmore from the University of British Columbia engages with Dr. Leigh Charvet and Dr. Giuseppina Pilloni, who break down their research on remotely supervised transcranial direct current stimulation (RS-tDCS). Their discussion focuses on the feasibility, safety, and real-world applications of home-based neurostimulation treatments for multiple sclerosis (MS), targeting symptoms like fatigue and hand dexterity. They also explore broader implications for the future of personalized and accessible neurorehabilitation and explain the mechanisms and potential of tDCS as a complementary treatment option, extending to areas like depression and addiction. The episode underscores the promise of integrating therapy into the home, providing valuable insights for clinicians, researchers, and individuals living with neurological disorders.

NYU Langone Clinical tDCS Service Program

https://nyulangone.org/care-services/tdcs-program?cid=sem_google&sem_campaign_id=22139905662&sem_ad_group_id=&sem_creative_id=&gad_source=1&gad_campaignid=22139906628&gbraid=0AAAAAC9qk2v7bAhjNaz7bDanP8kgj4JsH&gclid=CjwKCAjwo4rCBhAbEiwAxhJlCTSji-MZmNiT9pziGg86R4hb7Mst8JAEHawsJKYB3-vob28tdL4D0RoC2B0QAvD_BwE

Clinical Research Study: HRV-Guided tDCS: Integrating a Biomarker for Clinical Utility https://clinicaltrials.med.nyu.edu/clinicaltrial/2591/hrv-guided-tdcs-integrating-biomarker/

Clinical Research Study: Home-Based Transcranial Direct Current Stimulation (tDCS) for Depression in Multiple Sclerosis

https://clinicaltrials.gov/study/NCT06901687?cond=multiple%20sclerosis%20&intr=tDCS&rank=1

NYU Langone’s Neuromodulation Lab

https://med.nyu.edu/research/charvet-lab/

Publications

https://med.nyu.edu/research/charvet-lab/publications

00:00 Introduction to the Neurostimulation Podcast

02:06 Today's Episode: Remote Supervised tDCS for MS

03:38 Meet the Experts: Dr. Charvet and Dr. Pilloni

04:24 Dr. Charvet's Journey in Neurostimulation

06:18 Dr. Pilloni's Background and Research

08:30 The Importance of Remote Neurostimulation

11:05 Study Design and Methodology

13:11 Results and Implications of the Study

21:18 Challenges and Future Directions

26:50 Exploring Integrated Markers for Treatment Guidance

28:12 The Role of Biomarkers in Depression Studies

30:16 Mechanistic Studies and Brain Perfusion Insights

33:01 Broad Activation and Neuroplasticity

34:09 tDCS as a Complementary Treatment

37:09 Challenges and Safety in Home-Based tDCS

41:12 Accessibility and Future Directions

44:57 Cannabis Use and Neurostimulation

47:52 Closing Thoughts and Future Prospects

51:12 Final Remarks and Podcast Wrap-Up