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Antidepressants and Female Sexual Function: Mechanisms,Risks, and Clinical Solutions

DOI: 10.5281/zenodo.16239004

ABSTRACT

This episode explores how antidepressants—especially SSRIs,SNRIs, and NDRIs—uniquely affect sexual function in females, from adolescence through adulthood. It dives deep into the neurochemical underpinnings of drug-induced sexual dysfunction, known as AIDS (Antidepressant-Induced Sexual Dysfunction), and addresses the serious long-term risk of Post-SSRI Sexual Dysfunction (PSSD). The discussion outlines pharmacological mechanisms, symptom profiles, clinical challenges, and ethical considerations, particularly when treating adolescent girls. It also presents evidence-based strategies for prevention and treatment, including switching antidepressants, augmentation therapies, and non-pharmacologic interventions like exercise and sex therapy. Emphasis is placed on patient-centered care, informed consent, and preserving sexual health as a core component of well-being.

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OBJECTIVES

1. How does depression itself impact sexual function inwomen and girls?

2. What are the mechanisms behind sexual side effects ofSSRIs, SNRIs, and NDRIs?

3. How do serotonin, dopamine, and norepinephrine interactto influence sexual health?

4. What is the true incidence of antidepressant-inducedsexual dysfunction in females?

5. How does bupropion compare to serotonergic agents interms of sexual side effects?

6. What is Post-SSRI Sexual Dysfunction (PSSD), and why isit a serious clinical concern?

7. What are the special risks associated with prescribing toadolescent girls?

8. What management strategies (drug switches, augmentation, behavioral therapies) are supported by evidence?

Do you have insights, questions, or experiences related tosexual side effects of antidepressants? Drop a comment below and let's talk.

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#Antidepressants #SexualHealth #PSSD #SSRIs #SNRIs#Bupropion #WomensHealth #AdolescentMentalHealth #Neuropharmacology #InformedConsent #Psychiatry #PrecisionMedicine #publichealth #podcast #healthcare #women