A man returns to the town where a baffling murder took place 27 years earlier, determined to get to the bottom of the story. Just hours after marrying the beautiful Angela Vicario, everyone agrees, Bayardo San Roman returned his bride in disgrace to her parents. Her distraught family forced her to name her first lover; and her twin brothers announced their intention to murder Santiago Nasar for dishonoring their sister. Yet if everyone knew the murder was going to happen, why did no one intervene to stop it?

Candace Chen, a millennial drone self-sequestered in a Manhattan office tower, is devoted to routine. With the recent passing of her Chinese immigrant parents, she’s had her fill of uncertainty. She’s content just to carry on: She goes to work, troubleshoots the teen-targeted Gemstone Bible, watches movies in a Greenpoint basement with her boyfriend. So Candace barely notices when a plague of biblical proportions sweeps New York.

Yasodhara tells the story of her own Sinhala family, rich in love, with everything they could ask for. As a child in idyllic Colombo, social hierarchies, their parents’ ambitions, teenage love shape Yasodhara and her siblings’ lives, and, subtly, the differences between Tamil and Sinhala people; but the peace is shattered by the tragedies of war. Yasodhara's family escapes to Los Angeles. But Yasodhara's life has already become intertwined with a young Tamil girl's.

Grieving mother Magos cuts out a piece of her deceased eleven-year-old son Santiago's lung. Acting on fierce maternal instinct and the dubious logic of an old folktale, she nurtures the lung until it gains sentience, growing into the carnivorous little Monstrilio she keeps hidden within the walls of her family's decaying Mexico City estate. Eventually, Monstrilio begins to resemble the Santiago he once was, but his innate impulses—though curbed by his biological and chosen family's communal care—threaten to destroy this fragile second chance at life.

Mikage is an orphan raised by her grandmother, who has passed away. Grieving, Mikage is taken in by her friend, Yoichi, and his mother (who is really his cross-dressing father), Eriko. As the three of them form an improvised family that soon weathers its own tragic losses, Yoshimoto spins a lovely, evocative tale with the kitchen and the comforts of home at its heart.