Amid the heralded springtime traditions and fabulous splendor of the Kentucky Derby, two Boston couples—longtime friends—indulge in a once-in-a-lifetime getaway. The weekend feels like a winner. It’s a milestone-birthday present for the newly—and reluctantly—turned forty Drew Starling. Her husband, Nate, has spared no expense, despite the mounting gambling debts that Drew knows nothing about. He’s certain that with his lucky charm, Drew, by his side, he can reverse his misfortunes at Churchill Downs.

When Bunny Linden abandons her three children with her older sister, Jayne, in 1972, she knows Jayne will be the perfect mother. The mother Bunny, a teen runaway, could never be. As months turn into years without word, Jayne and her husband, Rodger, a rising journalism star, strive to give the children the opportunity to flourish and feel loved. When Jayne and Rodger finally have a child of their own, a seemingly stable home is built. But then, after nearly a decade, Bunny resurfaces and sets a chain of events in motion that detonates all their lives.

Remi Russell knows this playbook all too well. She’s seen it unfold five times over her six years at The Sophisticate, a once prominent but now struggling women’s magazine. So when the publication needs rescuing yet again, an intriguing new chief digital officer, Jason Ashbloome, arrives with a revolutionary plan beyond the usual workforce cuts. He proposes integrating MAUDE, an innovative AI software, to make the magazine more efficient. Remi fears she could lose her job to a machine, and worse, the magazine she loves might lose its humanity altogether.

In the summer of 1925, the winds of change are particularly chilling for a young woman whose life has suddenly become unbalanced. Devastated by her mother’s death and a cruel, broken engagement, Sadie Halloran learns that her great-aunt Marguerite, a renowned artist now in the throes of dementia, needs a live-in companion. Grasping at newfound purpose, Sadie leaves her desolate Kansas City boardinghouse for Blackberry Grange, Marguerite’s once-grand mansion sitting precariously atop an Arkansas bluff.

When seventeen-year-old Isla Richardson is killed in a hit-and-run incident, a community’s lives are thrown into disarray. For Isla’s mum, Abby, it is her second devastating bereavement, having lost her husband five years ago. As Abby begins to uncover secrets about Isla’s life, she’s forced to rethink everything she thought she knew about her family.

The president of the United States has terminal cancer. Chief of Staff Eli James, his faithful consigliere and best friend, is one of the few who know. But just as the president’s condition mysteriously improves, Eli’s hit with another blow: his daughter has cancer too. Hell-bent on helping her, Eli turns to Big Pharma’s top lobbyist for advice, but their encounter yields more questions than answers. As he races along a twisted trail to the truth, he stumbles upon a devastating cover-up worth billions of dollars—and millions of lives.

Reuben thought he’d spend the rest of his life with Beth, until she broke his heart six months ago. He’s not even remotely over her, so he’s devastated to hear she’s getting married—this weekend. Now he’s faced with the ultimate question: what should he do on the day of the wedding? Grieve? Disrupt the ceremony? Or do everything in his power to pretend it’s not happening? Enlisting the help of his friends, Reuben is all set to mark the occasion with distraction on a grand scale: Ferraris, champagne, and a VIP box at the races.

Traveling nurse Elizabeth May has a promising new home in Santa Cruz. And another new identity. It’s a pattern of reinvention for a woman escaping her traumatic childhood—and hiding from the decades of notoriety and destruction that followed. Invisibility has kept Elizabeth safe. Until now. After all these years, someone sees her for who she is. Threat by threat, a vengeful stalker is dismantling Elizabeth’s carefully constructed lifetime of lies. And no one in her temporary circle can be trusted.

After a difficult five years, at age forty-three, Nina Morgan Clarke’s time has finally arrived. With an ex-husband relocated across the country, her father bouncing back after the loss of his beloved wife, and her daughter, Xandra, thriving at boarding school, Nina is stepping into her dream job as a trifecta: a first-generation, Black female head of the storied Royal-Hawkins School. To mark the moment, Nina and her best friend, Marisol, take a long-overdue girls’ trip to celebrate the second half of Nina’s life—which is shaping up to be the best part of her life.

Nadia Fabiola wants to lose herself in Evergreen—the Jersey Shore town where she grew up vacationing with her family—and never look back at her glamorous, gainfully employed former self. After a shocking lupus diagnosis turned her life upside down, she’s desperate for a sense of control over her body, her life, and her mental health. Nadia plans on keeping her life small and boring, while continuing to ignore her sister’s relentless questioning.

Anne is barely keeping it together. A frazzled ghostwriter and aspiring novelist, she juggles nine-year-old twins and a listless marriage from an overcrowded Manhattan apartment, spreading herself thinner each day. Just as Anne is about to give up on her dreams, she lands her biggest client yet: Melody Wells. Melody paints a picture of serenity and empowerment in the lavender haze of her visualization workshops—however, the one thing she can’t manifest are the pages her publisher is demanding for her new motivational book. Enter Anne.

When Charlotte Sitterly’s husband is arrested for a white-collar crime, she and her daughter Iris are locked out of their house by the FBI and—what’s potentially even worse—thrust into the spotlight of @JuniperShoresSocialite, the town’s snarky anonymous Instagram account. Cut off from her bank accounts and feeling desperate, Charlotte takes up an acquaintance’s offer to stay at a beachfront former bed-and-breakfast that’s home to a community of single mothers and draws plenty of gossip in the small coastal North Carolina town.

Linda is doing her best to lead a life that would appear normal to the casual observer. Weekdays, she earns $20 an hour moderating comments for a video-sharing platform, then rides the bus home to the windowless garage she rents on the outskirts of San Francisco. But on the last Friday of each month, she indulges her true passion, taking BART to SFO for a round-trip flight to a regional hub. The destination is irrelevant, because each trip means a new date with a handsome stranger—a stranger with intelligent windscreens, sleek fuselages, and powerful engines.

Miranda’s parents live in a dilapidated house in rural France that they share with two llamas, eight ducks, five chickens, two cats, and a freezer full of food dating back to 1983. This wry, propulsive story about a singularly eccentric family and the sibling rivalry, generational divides, and long-buried secrets that shape them, is a glorious debut novel from a seasoned playwright with immense empathy and a flair for dialogue.

Sybil Van Antwerp has throughout her life used letters to make sense of the world and her place in it. Most mornings, around half past ten, Sybil sits down to write letters—to her brother, to her best friend, to the president of the university who will not allow her to audit a class she desperately wants to take, to Joan Didion and Larry McMurtry to tell them what she thinks of their latest books, and to one person to whom she writes often yet never sends the letter.