What would happen if Imperial Rome never fell? Roma Eterna, spanning fifteen hundred years of global history, follows the reign of the Roman Empire from its inception to the present day. Empire continues to expand, creeping across the globe and through the annals of history from the conquest of the Mayans to the first circumnavigational voyage, and finally the attempt of the Hebrews to flee Rome’s tyranny by escaping to another planet.

Four students discover a manuscript, The Book of Skulls, which reveals the existence of a sect, now living in the Arizona desert, whose members can offer immortality to those who can complete its initiation rite. To their surprise, they discover that the sect exists, and is willing to accept them as acolytes. But for each group of four who enter the rite, two must die in order for the others to succeed.

Captured by pirates and brought to the west coast of Africa, young British seaman Andrew Battell longs for his home in seventeenth-century England. His only hope of returning is to work hard and be awarded freedom by his Portuguese captors—a freedom he is consistently denied. As he is moved farther and farther inland, away from the coast and any hope of a boat back to England, Battell’s dreams of freedom begin to dwindle. Finally, taking matters into his own hands, he escapes and takes sanctuary among the Jaqqas, a tribe of cannibalistic warriors lead by the sinister Lord of Darkness.

Millions of years beyond our time, our Earth has long since stopped spinning—and giant flora have taken over the sunlit half of the motionless world. Here humans are among the very few animal species that still exist, struggling to survive against enormous odds, but they have become small and weak, and their numbers have dwindled to almost nothing. When the aging leader of Gren's tribe decrees it is time for the old ones to go "Up," the younger are left to make their own way below.

Graduate student Tom Rice is thrilled to embark on his first deep-space archeological expedition. He is part of a team from Earth, venturing out in search of artifacts from a civilization that ruled the universe many millennia ago. Called the High Ones, the members of this long-gone society left tantalizing clues about their history and culture scattered throughout space. One such clue, a "message cube" containing footage of the ancient ones, is more interesting than all of the others combined. It seems to indicate that the High Ones aren't extinct after all.