Jack Flanders and his crew sail to a mysterious island known as Key Diablo. When a fog moves in, all color seems to vanish, and everything turns into black and white. The islanders, dressed in clothes from the 1940s and '50s, appear to have stepped out of an old Hollywood film noir. And soon our heroes, Jack, Claudine, Mojo, Dominique, and Rose, find themselves playing characters that are dressed to kill.

While Jack Flanders is scuba diving in the great barrier reef off Belize, he discovers a sunken pirate ship. On board are two skeletons poised as though playing chess, and every time he returns, the pieces have been moved. One of the pieces looks a lot like Jack.

Mojo receives a call from "The Whistle Stop Hobby Shop". He's told his pocket watch has arrived. It's a gift from someone named "Rufus". But the pocket watch has no hands or numbers, just an opaque face that reminds Mojo of a zombie's eye. Mojo is mistaken for the detective, Rufus. He's hired to find Angelina, the missing sister of Philadelphia gangster Tony Rizzo. By using his watch as a portal, Mojo is able to look beyond the veils of this world, and he traces Angelina to a mysterious train.

While Jack Flanders is being chased by a zombie, his phone rings. It's Mojo waking Jack from his nightmare and inviting him to New Orleans. Later, strolling through the French Quarter, Jack is amazed to see Claudine, from Montreal. Or had he just met a voodoo priestess who can shapeshift into the woman of his dreams? And who is that zombie that keeps following him?

When a beautiful Indian woman hands Jack his own business card, which she claims he gave her Aunt over 40 years ago, there is no doubt in Jack's mind that another quest is about to unfold. Before the riddle is solved, Jack is off to India.

Jack Flanders encounters trolls, wizards, and all sorts of odd mythical creatures when he explores the "Invisible Realms" in search of our future Ah-Ha's - those spontaneous flashes of insight that have caused great thinkers to leap to their feet and shout, "Ah-Ha!".

A delightful vacation in Bali turns into something else as Jack is confronted with black magic, dreams, and spectral visits from a Balinese holy man who sends Jack through a circular doorway to a wold where those who step in rarely step out.

In the small Caribbean town of San Miguel, Jack and Mojo begin to hear stories of islands that appear and disappear. They soon discover there are strange ghost-like beings that visit the town when the islands appear. They are called, Luc-an-oona (those who bless us). But when one of Jack's crew visits the ghost island, strange things begin to happen.

Somewhere in the tropics, yet another beach resort is being built. As they bulldoze a road through a valley the locals consider sacred (the dwelling of a Nature Spirit), the jungle begins to spring up everywhere else. At Maria's Cafe', chairs are sprouting leaves, vines are creeping over the counter, and orchids are growing from the walls. Meanwhile, Jack, Mojo and Claudine are attempting to prove the Nature Spirit not only exists, she may have just begun to "even the score".

One autumn evening in New York, Jack Flanders walks into an all night coffee shop, and finds himself stepping out into the tropics. He encounters his long lost uncle, Sir Henry Jowls, who convinces Jack to steal a green stone. But Sir Henry is replaced by another Sir Henry, who insists Jack return the stone to the mythical city of Mer-Kahbah. To reach that city, Jack must cross the Twilight Realms of the Hungry Ghosts and they are quite hungry.