One Sunday afternoon in Southern California, Bert Cousins shows up at Franny Keating's christening party uninvited. Before evening falls, he has kissed Franny's mother, Beverly - thus setting in motion the dissolution of their marriages and the joining of two families.

Lillian and Madison were unlikely roommates and yet inseparable friends at their elite boarding school. But then, Lillian had to leave the school unexpectedly in the wake of a scandal, and they’ve barely spoken since. Until now, when Lillian gets a letter from Madison pleading for her help. Madison’s twin stepkids are moving in with her family, and she wants Lillian to be their caretaker. However, there’s a catch: The twins spontaneously combust when they get agitated, flames igniting from their skin in a startling but beautiful way.

It's a winter evening in Boston and the temperature has drastically dropped as a blizzard approaches the city. On this fateful night, Bernard Doyle plans to meet his two adopted sons, Tip the older, and more serious and Teddy, the affectionate dreamer, at a Harvard auditorium to hear a speech given by Jesse Jackson. Doyle, an Irish Catholic and former Boston mayor, has done his best to keep his two sons interested in politics, from the day he and his now deceased wife became their parents, through their childhoods, and now in their lives as college students.

St. Elizabeth’s, a home for unwed mothers in Habit, Kentucky, usually harbors its residents for only a little while. Not so Rose Clinton, a beautiful, mysterious woman who comes to the home pregnant but not unwed, and stays. She plans to give up her child, thinking she cannot be the mother it needs. But when Cecilia is born, Rose makes a place for herself and her daughter amid St. Elizabeth’s extended family of nuns and an ever-changing collection of pregnant teenage girls.

Somewhere in South America, at the home of the country's vice president, a lavish birthday party is being held in honor of the powerful businessman Mr. Hosokawa. Roxanne Coss, opera's most revered soprano, has mesmerized the international guests with her singing. It is a perfect evening—until a band of gun-wielding terrorists takes the entire party hostage.