London, 1846. Ramshackle and crumbling, St Saviour's Infirmary awaits demolition. Within its stinking wards and cramped corridors the doctors bicker and fight. Ambition, jealousy and hatred seethe beneath the veneer of professional courtesy. Always an outsider, and with a secret of her own to hide, apothecary Jem Flockhart observes everything, but says nothing. And then six tiny coffins are uncovered, inside each a handful of dried flowers and a bundle of moldy rags.

The Earl of Wrexford possesses a brilliant scientific mind, but boredom and pride lead him to reckless behavior. He does not suffer fools gladly. So when pompous, pious Reverend Josiah Holworthy publicly condemns him for debauchery, Wrexford unsheathes his rapier-sharp wit and strikes back. As their war of words escalates, London's most popular satirical cartoonist, A. J. Quill, skewers them both.

Before Jack the Ripper terrorised London, Police Inspector Samuel Ravenscroft patrolled the streets of Whitechapel. Clever and hard-working, Ravenscroft nonetheless has the worst record in the force. He lets a murderer escape during a chase and is banished to the spa town of Malvern for a water treatment to cure his asthma. Ravenscroft accepts a dinner invitation from a new acquaintance, Jabez Pitzer. Before dinner, the maid finds Pitzer slumped over his desk - dead. Ravenscroft immediately recognises the signs - Pitzer has been poisoned.

June 1910. Fighting her corner in a man’s world, Dr. Margaret Demeray works as a pathologist in a London hospital for the poor. Suppressing her worry that she’s breaching confidentiality, Margaret gives a stranger called Fox information about a dead down-and-out, in the hope he’ll use it to raise awareness of bad working conditions. But when a second man appears to die the same way, Margaret starts to wonder why the enigmatic Fox keeps turning up to ask ever more complex questions. She decides to work alone, uncertain of his motives and wary of her attraction to him.

London, 1880. When accounts clerk Ernest Stibbins approaches the World's End investigation bureau with wild claims that his wife Albertina has been warned by her spirit guides that someone is out to harm her, the bureau's owner Lily Raynor and her new employee Felix Wilbraham are sceptical. How are the two private enquiry agents supposed to investigate threats from beyond the grave? But after she attends a seance at the Stibbins family home, Lily comes to realize that Albertina is in terrible danger. And soon, so is Lily herself....