Twenty-eight-year-old Sean McGillin is the picture of health, until he fractures his leg while in-line skating in New York City's Central Park. Within 24 hours of his surgery, he dies.

When Dr. Caden Taggart saw the two men sitting in his waiting room, he didn’t think they were patients. He was right, and when they introduced themselves as agents of the Drug Enforcement Agency, things started to get bad. Then Caden felt as though someone had gut-punched him when his father, Dr. Henry Taggart, told him he probably had carcinoma of the pancreas. When he talked about his son assisting with his suicide, Caden wondered how he could talk him out of that.

Dr. Tyler Gentry had it all planned out, but the death of his parents in a plane crash changed everything. When he discovered his father had left him a mountain of debt, piled on top of his own student debt, the offer from Dr. William Hall to join his group of surgeons seemed a perfect solution. But the night before he was to start, Tyler received a call that told him to get out while he could. Despite the salary and perks, Tyler found a curtain of mystery surrounding the surgical group.

Dr. Kelly Irving knew her husband, attorney Jack Harbaugh, was acting strangely but figured they’d get through it. When she backed out of her garage that morning, she thought her car hit a bump. Instead, its progress was stopped by the body of a man her husband recently represented. The dead man had been shot by her husband’s gun. Jack was a primary suspect. Kelly couldn’t decide if Jack was a murderer or marked as the next victim. They were forced to put their marital differences aside and concentrate on keeping Jack alive while discovering who was behind the whole thing.

The colored lights on the snow gave it a holiday appearance, but the dead woman's body in the yard added a grisly touch. How did Ina Bell Patrick die? Who killed her? And why? The dead woman had no direct heirs, so two nephews and a niece stood to inherit. Dr. Laura Morris was left to make all the arrangements, attorney Roger Morris could certainly use the money, and Zack Morris had disappeared two years earlier.

Frankie Elkin is an average middle-aged woman, a recovering alcoholic with more regrets than belongings. But she spends her life doing what no one else will - searching for missing people the world has stopped looking for. When the police have given up, when the public no longer remembers, when the media has never paid attention, Frankie starts looking. A new case brings her to Mattapan, a Boston neighborhood with a rough reputation. She is searching for Angelique Badeau, a Haitian teenager who vanished from her high school months earlier.

The box contained a cell phone, which rang as soon as she opened the package. A voice that called Dr. Kathy Hoover by name said that her husband had been kidnapped. To get him back, she would have to poison one of her patients. At first, she didn’t believe that her husband had been taken from the conference he was attending, but soon she discovered that the kidnappers really had Darren. If she wanted to see him again, she had to give medication that would murder Kelton Rush, former Vice-President. What was she to do? How would she handle this critical decision?

Medical student Amy Brenner is spending the night on a locked psychiatric ward. Amy has been dreading her evening working on Ward D, the hospital’s inpatient mental health unit. There are very specific reasons why she never wanted to do this required overnight rotation. Reasons nobody can ever find out. And as the hours tick by, Amy grows increasingly convinced something terrible is happening within these tightly secured walls.

Quinn Alexander has committed an unthinkable crime. To avoid spending her life in prison, Quinn makes a run for it. She leaves behind her home, her job, and her family. She grabs her passport and heads for the northern border before the police can discover what she's done. But when an unexpected snowstorm forces her off the road, Quinn must take refuge at the broken-down, isolated Baxter Motel. The handsome and kindly owner, Nick Baxter, is only too happy to offer her a cheap room for the night. Unfortunately, the Baxter Motel isn't the quiet safe haven it seemed to be.

In the slums of 1880s New York, Una Kelly has grown up to be a rough-and-tumble grifter, able to filch a pocketbook in five seconds flat. But when another con-woman pins her for a murder she didn't commit, Una is forced to flee. Running from the police, Una lies her way into an unlikely refuge: the nursing school at Bellevue Hospital.

Though a small town at heart, Lawrenceton, Georgia, has its dark side - and its crime buffs. One of them is librarian Aurora "Roe" Teagarden, a member of the Real Murders Club, which meets once a month to analyze famous cases. It's a harmless pastime - until the night she finds a member killed in a manner that eerily resembles the crime the club was about to discuss.

Rescuing a kidnapped child is part of the job for search-and-rescue K-9 handler Patrick Sanders—but this time it's his son. Now Patrick and his furry partner must work with his high school love, Jennie Wilcox, to shield the little boy he just learned about. In a hurricane's aftermath, Detective Erin Jeffries is stunned when she and her K-9, Alcee, uncover a collapsed building's only survivor—her long-ago ex, Cody Elbourne .When park ranger Autumn Mercer and her K-9 partner, Sherlock, meet a stranger in the mountains whose brother is injured, they drop everything to help.

Tranquility, Maine seems like the perfect place for Dr. Claire Elliot to shelter her adolescent son from the distractions of the big city - until a deadly epidemic threatens to destroy everyone she loves.

After a harrowing attempt on a judge's life at the courthouse, Deputy US Marshals Madison James and Jonas Quinn are tasked with finding a missing woman and an endangered child in connection to the murder of the judge's wife. What seems like a straightforward case becomes hopelessly tangled when the marshals discover that the woman they are searching for is in witness protection and the Amber Alert put out for the missing child has put two lives in danger. Madison and Jonas are forced into a race to find the woman and the child before the men who want her dead discover her location.

Katie LeClair has finally settled down as the new doctor in Baxter, Michigan. After years of moving, schooling, and training, she wants nothing more than to find a place she can call home, and a small town outside of Ann Arbor seems perfect. Katie quickly gets to work in building a life for herself in Baxter, and beyond reviving her love life, she also finds a pair of business partners in a team of father and son family practitioners. But that idyllic dream is immediately shattered when one of her patients is found dead.