In a Philadelphia neighborhood rocked by the opioid crisis, two once-inseparable sisters find themselves at odds. One, Kacey, lives on the streets in the vise of addiction. The other, Mickey, walks those same blocks on her police beat. They don't speak anymore, but Mickey never stops worrying about her sibling. Then Kacey disappears, suddenly, at the same time that a mysterious string of murders begins in Mickey's district, and Mickey becomes dangerously obsessed with finding the culprit - and her sister - before it's too late.

Ada Sibelius is raised by David, a single father and head of a computer science lab in Boston. Homeschooled, she accompanies her loving father - brilliant, eccentric, socially inept - to work every day. By 12 she is a painfully shy prodigy. At the same time that the lab begins to gain acclaim, David's mind begins to falter, and his mysterious past comes into question. When her father moves into a nursing home, Ada is taken in by one of David's colleagues. She embarks on a mission to uncover her father's secrets.

Forrmer academic Arthur Opp weighs 550 pounds and hasn’t left his rambling Brooklyn home in a decade. Twenty miles away in Yonkers, seventeen-year-old Kel Keller navigates life as the poor kid in a rich school and pins his hopes on what seems like a promising baseball career - if he can untangle himself from his family drama.

Early morning, August 1975: a camp counselor discovers an empty bunk. Its occupant, Barbara Van Laar, has gone missing. Barbara isn’t just any thirteen-year-old: she’s the daughter of the family that owns the summer camp and employs most of the region’s residents. And this isn’t the first time a Van Laar child has disappeared. Barbara’s older brother similarly vanished fourteen years ago, never to be found.

Duchess Day Radley is a 13-year-old self-proclaimed outlaw. Rules are for other people. She is the fierce protector of her five-year-old brother, Robin, and the parent to her mother, Star, a single mom incapable of taking care of herself, let alone her two kids. Walk has never left the coastal California town where he and Star grew up. He may have become the chief of police, but he’s still trying to heal the old wound of having given the testimony that sent his best friend, Vincent King, to prison decades before. And he's in overdrive protecting Duchess and her brother.