World renowned neurosurgeon Jon Ritter is on the verge of a medical breakthrough that will change the world. His groundbreaking surgical treatment, using transplanted non-human stem cells, is set to eradicate the scourge of Alzheimer’s disease and give hope to millions. But when the procedure is slated for testing, it all comes to an abrupt and terrifying halt.

When Matthew Preston was eight, his father was shot and killed in rarefied Pacific Palisades by Ted Nash, a home burglar who happened to be the Prestons' neighbor. Though Nash was sentenced to life in San Quentin, Matthew's lifelong obsession is to somehow get into the prison, gain access to Nash, and exact the ultimate personal revenge. He devises a plan to become a prison doctor to gain access to Nash.

Martin Clark has been praised as "part John Grisham, part Hunter S.Thompson, and part sheer grit". Mason Hunt returns to his small Virginia hometown as the county's commonwealth attorney. Mason's brother Gates, who's currently serving a 20 year prison term, thinks Mason should have enough pull to set him free. And when Mason refuses, Gates hatches a plan to destroy his brother's life with a secret they both swore they'd take to the grave.

While speaking at a Hong Kong medical conference, neurosurgeon Dr. Lucas McCrae slips the cloth off a cadaver's head during a routine medical demonstration, and is overwhelmed with the shock by what's staring back at him: His best friend, Andy Baer. Stunned, McCrae races back to Seattle to discover that Andy is in fact missing and may have been murdered by a gang of body snatchers who operate a legit funeral business and make a fortune by selling recovered body parts to medical researchers.

Dr. Rhea Lynch left a suffocating life in Charleston to practice medicine in the ER of a small South Carolina Hospital. Now, Dawkins County is her home, a place that holds the only real family she's ever known. But when she returns from vacation, Rhea is shocked to discover that her best friend, Marisa, is near death and unable to communicate. The official diagnosis: a paralyzing stroke. Despite the family's attempts to keep her away, Rhea is determined to make her own diagnosis.