The three Blue sisters are exceptional—and exceptionally different. Avery, the eldest and a recovering heroin addict turned strait-laced lawyer, lives with her wife in London; Bonnie, a former boxer, works as a bouncer in Los Angeles following a devastating defeat; and Lucky, the youngest, models in Paris while trying to outrun her hard-partying ways. They also had a fourth sister, Nicky, whose unexpected death left the family reeling. A year later, as they each navigate grief, addiction and ambition, they find they must return to New York to stop the sale of the apartment they were raised in.

In 1985, Yale Tishman, the development director for an art gallery in Chicago, is about to pull off an amazing coup, bringing in an extraordinary collection of 1920s paintings as a gift to the gallery. Yet as his career begins to flourish, the carnage of the AIDS epidemic grows around him. One by one, his friends are dying and after his friend Nico's funeral, the virus circles closer and closer to Yale himself. Soon the only person he has left is Fiona, Nico's little sister.

Anna Maria has only known life inside the Pietà, an orphanage for children born of prostitutes. But the girls of the Pietà are lucky in a sense: most babies born of their station were drowned in the city’s canals. And despite the strict rules, the girls are given singing and music lessons from an early age. The most promising musicians have the chance to escape the fate of the rest: forced marriage to anyone who will have them.

When Mae and Ari meet outside a crowded gay bar during their final year of university, their connection is instant, sparking a lifetime friendship. Stubborn and no stranger to breaking hearts, Mae needs Ari's bright light to guide her out of her self-centered ways. Reeling from a scandal in New York, vibrant, charming Ari sees Mae as an anchor keeping him grounded. Though they are young, ambitious, and queer, both Mae and Ari secretly daydream about settling down somewhere with a garden, children, and dogs, building a life that feels like home.

Beverly Underwood and her arch enemy, Lula Dean, live in the tiny town of Troy, Georgia, where they were born and raised. Now Beverly is on the school board, and Lula has become a local celebrity by embarking on mission to rid the public libraries of all inappropriate books—none of which she’s actually read. To replace the “pornographic” books she’s challenged at the local public library, Lula starts her own lending library in front of her home: a cute wooden hutch with glass doors and neat rows of the worthy literature that she’s sure the town’s readers need.