In our latest episode, we’re extremely fortunate to be joined by evolutionary virologist and avian influenza researcher Dr. Louise Moncla to discuss the current H5N1 situation in the U.S. and around the world. We cover the history of H5N1, how the virus might mutate, the current risks to both animal and human populations, and the potential for a future pandemic. Dr. Moncla also shares insight into her work on surveillance, highly pathogenic avian influenza (HPAI) tracking, and vaccine development. For anyone looking to better understand H5N1 or curious about what the current outbreak might lead to, this episode is a must-listen.Dr. Louise H. Moncla is an assistant professor of pathobiology at the University of Pennsylvania School of Veterinary Medicine, where she leads cutting-edge research on the evolution of avian influenza viruses, including highly pathogenic H5N1 strains. Her work focuses on understanding how these viruses adapt across hosts—especially during zoonotic spillover events—by combining computational phylodynamics, population genetics, and experimental virology.

Dr. Moncla has contributed to major surveillance efforts, including the development of a Nextstrain dashboard tracking H5N1 evolution in cattle, where her team identified key mutations suggesting mammalian adaptation.

She has briefed lawmakers on the current H5N1 crisis and is frequently cited by organizations like the WHO and USDA. Her publications include studies on within-host evolution in humans and poultry, and she is a co-author of the Nature paper on the global H5N1 panzootic.

In recognition of her impactful work, Dr. Moncla was named a 2024 Pew Biomedical Scholar. Her research is helping shape how we understand, monitor, and respond to emerging pandemic threats.