Canine Diluted Coat Alopecia
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Canine Diluted Coat Alopecia
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Canine Diluted Coat Alopecia (CDCA), is a genetic skin condition affecting dogs with diluted coat colors. This podcast explains the genetic basis linked to mutations in the MLPH gene, detailing how these mutations lead to abnormal melanin distribution and fragile hair structures. And it covers the prevalence, predisposed breeds, and the clinical signs, such as progressive hair loss on diluted areas of the body, often accompanied by skin issues. It also outlines the diagnostic process, including clinical examination, hair analysis, and skin biopsies, while discussing the limitations of genetic testing in predicting the severity of the condition due to incomplete penetrance and modifying factors. Finally, it addresses the symptomatic management of CDCA, emphasizing topical treatments and infection control, and highlights the importance of responsible breeding practices to prevent its occurrence.