Between 1999 and 2017, an estimated 250,000 Americans died from overdoses involving prescription painkillers, a plague ignited by Purdue Pharma’s aggressive marketing of OxyContin. Families, working class and wealthy, have been torn apart, businesses destroyed, and public officials pushed to the brink. Meanwhile, the drugmaker’s owners, Raymond and Mortimer Sackler, whose names adorn museums worldwide, made enormous fortunes from the commercial success of OxyContin.

The opioid epidemic has been described as "one of the greatest mistakes of modern medicine." But calling it a mistake is a generous rewriting of the history of greed, corruption, and indifference that pushed the US into consuming more than 80 percent of the world's opioid painkillers. Journeying through lives and communities wrecked by the epidemic, Chris McGreal reveals not only how Big Pharma hooked Americans on powerfully addictive drugs but the corrupting of medicine and public institutions that let the opioid makers get away with it.

From the New York Times best-selling author of Dreamland, a searing follow-up that explores the terrifying next stages of the opioid epidemic and the quiet yet ardent stories of community repair.

In 1929, in the blue-collar city of Portsmouth, Ohio, a company built a swimming pool the size of a football field; named Dreamland, it became the vital centre of the community. Now, addiction has devastated Portsmouth, as it has hundreds of small rural towns and suburbs across America—addiction like no other the country has ever faced. How that happened is the riveting story of Dreamland.

Profanity has always been a deliciously vibrant part of our lexicon, an integral part of being human. In fact, our ability to curse comes from a different part of the brain than other parts of speech - the urgency with which we say "f--k!" is instead related to the instinct that tells us to flee from danger. Language evolves with time, and so does what we consider profane or unspeakable. Nine Nasty Words is a rollicking examination of profanity, explored from every angle: historical, sociological, political, linguistic.

By following the struggle for survival of one small-town hospital, and the patients who walk, or are carried, through its doors, The Hospital takes listeners into the world of the American medical industry in a way no audiobook has done before. Americans are dying sooner, and living in poorer health. Alexander argues that no plan will solve America’s health crisis until the deeper causes of that crisis are addressed.

In 2011, a 26-year-old libertarian programmer named Ross Ulbricht launched the ultimate free market: the Silk Road, a clandestine website hosted on the Dark Web where anyone could trade anything - drugs, hacking software, forged passports, counterfeit cash, poisons - free of the government's watchful eye. It wasn't long before the media got wind of the new website where anyone - not just teenagers and weed dealers but terrorists and black hat hackers - could buy and sell contraband detection-free.

The prize-winning and best-selling author of Say Nothing presents a grand, devastating portrait of three generations of the Sackler family, famed for their philanthropy, whose fortune was built by Valium and whose reputation was destroyed by OxyContin. Empire of Pain is a masterpiece of narrative reporting and writing, exhaustively documented and ferociously compelling.

The definitive investigation and exposé of how some of the nation's largest corporations created and fueled the opioid crisis—from the Pulitzer Prize-winning Washington Post reporters who first uncovered the dimensions of the deluge of pain pills that ravaged the country and the complicity of a near-omnipotent drug cartel.

From blurry vision to crooked teeth, ACLs that tear at alarming rates and spines that seem to spend a lifetime falling apart, it's a curious thing that human beings have beaten the odds as a species. After all, we're the only survivors on our branch of the tree of life. Why is it that human mothers have such a life-endangering experience giving birth? And why are there entire medical specialties for teeth and feet? In this funny, wide-ranging and often surprising book, biologist Alex Bezzerides tells us just where we inherited our achy, brilliant bodies in the process of evolution.

Coffee is an indispensable part of daily life for billions of people around the world - one of the most valuable commodities in the history of global capitalism, the leading source of the world's most popular drug, and perhaps the most widespread word on the planet. Augustine Sedgewick's Coffeeland tells the hidden and surprising story of how this came to be, tracing coffee's 500-year transformation from a mysterious Muslim ritual into an everyday necessity.

Devil Take the Hindmost is a lively, original, and challenging history of stock market speculation from the 17th century to the present day. Edward Chancellor traces the origins of the speculative spirit back to ancient Rome and chronicles its revival in the modern world.

From an award-winning Fortune reporter, an explosive narrative investigation of the generic drug boom that reveals the life-threatening dangers posed by globalization - The Jungle for pharmaceuticals.

Redefining our traditional understanding of the New Deal, Fear Itself finally examines this pivotal American era through a sweeping international lens that juxtaposes a struggling democracy with enticing ideologies like Fascism and Communism. Ira Katznelson, "a towering figure in the study of American and European history" (Cornel West), boldly asserts that, during the 1930s and 1940s, American democracy was rescued yet distorted by a unified band of southern lawmakers who safeguarded racial segregation as they built a new national state to manage capitalism and assert global power.

Crystal methamphetamine is widely considered to be the most dangerous drug in the world, and nowhere is that more true than in the small towns of the American heartland. Methland tells the story of Oelwein, Iowa (pop. 6,159), which, like thousands of other small towns across the country, has been left in the dust by the consolidation of the agricultural industry, a depressed local economy, and an out-migration of people.

Two days after Christmas, 2011, Russel Faria returned to his Troy, Missouri, home to find his wife, Betsy, dead, a knife still lodged in her neck. She had been stabbed 55 times in a brutal murder that would set off a chain of events leading to one man's wrongful conviction and imprisonment, another man's death, the revelation of a diabolical scheme, and an astounding miscarriage of justice left unresolved for another 10 years.

When Vonlee "Nicole" Titlow and her aunt, Billie Jean Rogers, came home from a night of gambling in a casino near Detroit, they told police they found Billie's husband unconscious on the floor of the Rogers' mansion. Just another of his alcoholic benders, they assumed. But this time, Donald Rogers didn't wake up.

A deeply human story, Fentanyl, Inc. is the first deep-dive investigation of a hazardous and illicit industry that has created a worldwide epidemic, ravaging communities and overwhelming and confounding government agencies that are challenged to combat it.

In 2015, Mary Yoder returned home from the chiropractic center that she operated with her husband, Bill, complaining that she felt unwell. Mary, health-conscious and vibrant, was suddenly vomiting, sweating, and weak. Doctors in the ER and ICU were baffled as to the cause of her rapidly progressing illness. Her loved ones - including Bill and their children, Adam, Tamryn, and Liana - gathered in shock to say good-bye. In the weeks that followed Mary's death, the grief-stricken family received startling news from the medical examiner: Mary had been deliberately poisoned with colchicine.

Lacey Spears made international headlines in January 2015, when she was charged with the "depraved mind" murder of her five-year-old son, Garnett. Prosecutors alleged that the 27-year-old mother had poisoned him with high concentrations of salt through his stomach tube. To the outside world, Lacey had seemed like the perfect mother, regularly posting dramatic updates on her son's harrowing medical problems. But in reality, Lacey was a textbook case of Munchausen Syndrome by Proxy.

On January 11, 1995, deputies outside Austin, Texas, found a mutilated body laid across a cold campfire—head destroyed, hands cut off, skin singed by fire. In less than three days, they had the kill zone: a small apartment, where shy Christopher Hatton was shot at point blank range in his bed.

On July 13, 2011, Laura Jean Ackerson of Kinston, North Carolina, went to pick up her two toddler sons. It would be the last time she was seen alive. Laura's ex, Grant Hayes - the father of her two sons - and his wife, Amanda, the mother of his newborn daughter, both pointed the finger at each other as the one guilty of murdering Laura, cutting up her body, and then transporting and disposing of the remains on the shores of Oyster Creek, Texas.

As a private banker working for the largest bank in the world, UBS, Bradley Birkenfeld was an expert in Switzerland's shell-game of offshore companies and secret numbered accounts. He wined and dined ultrawealthy clients whose millions of dollars were hidden away from business partners, spouses, and tax authorities. As his client list grew, Birkenfeld lived a life of money, fast cars, and beautiful women, but when he discovered that UBS was planning to betray him, he blew the whistle to the US government.

In The Murders That Made Us, the story of the San Francisco Bay Area unfolds through its most violent and depraved acts. From the city's earliest days, where vigilantes hung perps from buildings and newspaper publishers shot it out on Market Street, to the kidnapping of Patty Hearst and the Zodiac Killer, crime has made the people of San Francisco who they are. Murder and mayhem are intertwined with the city's art, music, and politics.

A fierce memoir of a mother's murder, a daughter's coming-of-age in the wake of immense loss, and her ultimate mission to know the woman who gave her life.

In 1988 a troubled young man and his flamboyant mother were arrested for murdering a wealthy widow in her New York City mansion. Suddenly America was transfixed by a pair of real-life film noir characters. The media couldn't get enough of the twisted relationship between Sante Kimes and her 23-year-old son Kenny. But the most chilling story of all was never told - until now. Kent Walker, Sante's elder son, reveals how he survived 40 years of "the Dragon Lady's" very special brand of motherly love and still managed to get away.

As investigators brought out the bagged remains of several dozen young men from a small Chicago ranch home and paraded them in front of a crowd of TV reporters and spectators, attention quickly turned to the owner of the house. John Gacy was an upstanding citizen, active in local politics and charities, famous for his themed parties and appearances as Pogo the Clown. But in the winter of 1978-79, he became known as one of many so-called “sex murderers” who had begun gaining notoriety in the random brutality of the 1970s.

It seemed like the perfect romantic afternoon: a kayaking trip for two on the Hudson River. But it ended in tragedy when beautiful, blonde Angelika Graswald called 911 to report that her fiance, the handsome and athletic Vincent Viafore, had fallen into the choppy frigid waters. Authorities assumed it was an accident. But when the bereft bride-to-be posted videos of herself doing cartwheels on social media - shortly before Vincent's body was found - suspicions of murder rose to the surface.

Chris Watts was a family man. Everybody, including his family, believed that. Yet, on August 13, 2018, he murdered Shanann, his pregnant wife, and two young daughters. As terrible as his story is, it is also a warning because to this day, living behind bars, Watts is still acting out the character traits that made him kill in the first place.

The romance of the West is built on an endless armature of shootouts and train robberies, cowboys versus Indians, white hat versus black, and everybody versus the wilderness. From John Colter's harrowing escape from the Blackfeet to Hugh Glass' six-week crawl to civilization after a grizzly attack, from Custer's final moments to John Wesley Powell's treacherous run through the rapids of the Grand Canyon, Cowboys, Mountain Men, and Grizzly Bears takes the top 50 wildest episodes in the region's history and presents them to the listener in one convenient, narrative-driven package.