Isaac is at a crossroads in his young life. Growing up in Missouri, the son of a caustic, hard-driving father, he was conditioned to suppress his artistic pursuits and physical desires, notions that didn’t align with a traditional view of masculinity. But now, in late ’80s Chicago, Isaac has finally carved out a life of his own. He is sensitive and tenderhearted and has built up the courage to seek out a community. Yet just as he begins to embrace who he is, two social catalysts—the AIDS crisis and Rodney King’s attack—collectively extinguish his hard-earned joy.

Corsica, 1993. As a sun-drenched Mediterranean summer heads into full swing, beautiful and brash seventeen-year-old Séverine Guimard is counting down the days until graduation, dreaming of stardom while smoking cigarettes, and seducing boys in her class to pass the time. The pampered French American daughter of a politician, Séverine knows she’s destined for bigger things.

In the wake of a catastrophic storm, Cora sets off with her nine-year-old daughter, Maia, to register her son's birth. Her husband, Gordon, a local doctor, respected in the community but a terrifying and controlling presence at home, intends for her to name the infant after him. But when the registrar asks what she'd like to call the child, Cora hesitates...

In the spring of 1995, Nate Cartwright has lost everything: his parents are dead, his only brother wants nothing to do with him, and he's been fired from his job as a journalist in Washington, DC. With nothing left to lose, he returns to his family's summer cabin outside the small mountain town of Roseland, Oregon, to try and find some sense of direction. The cabin should be empty. It's not. Inside is a man named Alex. And with him is an extraordinary ten-year-old girl who calls herself Artemis Darth Vader. Artemis, who isn't exactly as she appears.

Birdie’s keeping it together; of course she is. So she’s a little hungover, sometimes, and she has to bring her daughter, Emaleen, to her job waiting tables at an Alaskan roadside lodge, but she’s getting by as a single mother in a tough town. Still, Birdie can remember happier times from her youth, when she was free in the wilds of nature. Arthur Neilsen, a soft-spoken and scarred recluse who appears in town only at the change of seasons, brings Emaleen back to safety when she gets lost in the woods. Most people avoid him, but to Birdie, he represents everything she’s ever longed for.

When a shocking murder occurs in the home of Angie and David Sheehan, their lives are shattered. Desperate to defend their family, they turn to small-town lawyer Martine Dumont for help, but Martine isn’t just legal counsel—she’s also the mother of Angie’s first love, Julian, a now-successful New York City criminal defense attorney. As Julian and Angie confront their shared past and long-buried guilt from a tragic accident years ago, they must navigate their own culpability and the unresolved feelings between them.

A professor named Cristina Rivera Garza stumbles upon the corpse of a mutilated man in a dark alley and reports it to the police. When shown a crime scene photo, she finds a stark warning written in tiny print with coral nail polish on the brick wall beside the body: “Beware of me, my love / beware of the silent woman in the desert.”

In the fall of 1959, Freda Gilroy arrives on the campus of Fisk University full of hope, carrying a suitcase and the voice of her father telling her she’s part of a family legacy of greatness. Soon, the ugliness of the Jim Crow South intrudes, and she’s thrust into a movement for social change. Freda is reluctant to get involved, torn between a soon-to-be doctor her parents approve of and an audacious young man willing to risk it all in the name of justice.

Tony Malik, a half-Irish, half-Arab FBI agent based in New York, specializes in tracking money from drug and arms deals. His life takes a dramatic turn when a long-term relationship ends and his job hangs in the balance. Amid personal turmoil, Malik becomes intrigued by his Palestinian father's past. He decides to visit his ancestral homeland for his niece's wedding, accepting a seemingly simple FBI assignment along the way.

When ten-year-old Ebby Freeman heard the gunshot, time stopped. And when she saw her brother, Baz, lying on the floor surrounded by the shattered pieces of a centuries-old jar, life as Ebby knew it shattered as well. The crime was never solved—and because the Freemans were one of the only Black families in a particularly well-to-do enclave of New England—the case has had an enduring, voyeuristic pull for the public. The last thing the Freemans want is another media frenzy splashing their family across the papers, but when Ebby's high profile romance falls apart, that's exactly what they get.

Birdie’s keeping it together; of course she is. So she’s a little hungover, sometimes, and she has to bring her daughter, Emaleen, to her job waiting tables at an Alaskan roadside lodge, but she’s getting by as a single mother in a tough town. Still, Birdie can remember happier times from her youth, when she was free in the wilds of nature. Arthur Neilsen, a soft-spoken and scarred recluse who appears in town only at the change of seasons, brings Emaleen back to safety when she gets lost in the woods. Most people avoid him, but to Birdie, he represents everything she’s ever longed for.

In 1943, when a frail old white woman shows up in Red Clay, Alabama, at the home of a Black former slave—on the morning following his funeral—his family hardly knows what to expect after she utters the words “… a lifetime ago, my family owned yours.” Adelaide Parker has a story to tell—one of ambition, betrayal, violence, and redemption—that shaped both the fate of her family and that of the late Felix H. Parker. But there are gaps in her knowledge, and she’s come to Red Clay seeking answers from a family with whom she shares a name and a history that neither knows in full.

In the spring of 1995, Nate Cartwright has lost everything: his parents are dead, his only brother wants nothing to do with him, and he's been fired from his job as a journalist in Washington, DC. With nothing left to lose, he returns to his family's summer cabin outside the small mountain town of Roseland, Oregon, to try and find some sense of direction. The cabin should be empty. It's not. Inside is a man named Alex. And with him is an extraordinary ten-year-old girl who calls herself Artemis Darth Vader. Artemis, who isn't exactly as she appears.

The three Blue sisters are exceptional—and exceptionally different. Avery, the eldest and a recovering heroin addict turned strait-laced lawyer, lives with her wife in London; Bonnie, a former boxer, works as a bouncer in Los Angeles following a devastating defeat; and Lucky, the youngest, models in Paris while trying to outrun her hard-partying ways. They also had a fourth sister, Nicky, whose unexpected death left the family reeling. A year later, as they each navigate grief, addiction and ambition, they find they must return to New York to stop the sale of the apartment they were raised in.

Heir to a fortune, Marguerite is destined for a life of prosperity and gentility. Then she is orphaned, and her guardian—an enigmatic and volatile man—spends her inheritance and insists she accompany him on an expedition to New France. That journey takes a unexpected turn when Marguerite, accused of betrayal, is brutally punished and abandoned on a small island.