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When a postwar search for London lodgings introduces ailing doctor John H. Watson to quirky chemist Sherlock Holmes, their collaboration in the art of observation and deduction begins. Congenial flatmates and even better colleagues, the pair is quickly drawn into a case of murder and revenge that has Scotland Yard at their wits’ end.

When Lord Edgware is found murdered the police are baffled. His estranged actress wife was seen visiting him just before his death and Hercule Poirot himself heard her brag of her plan to "get rid" of him. But how could she have stabbed Lord Edgware in his library at exactly the same time she was seen dining with friends? It's a case that almost proves to be too much for the great Poirot.