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Three die in a psychiatric hospital. A triple homicide. A contagion, deadly and mysterious, is the killer’s weapon of choice. A dart flies. A woman dies in the shower, her neck is punctured. A homicide, hours from Chicago. Poison, deadly and concocted, is the killer’s weapon of choice. As her city teeters on the verge of panic, Detective Rylee Hayes is forced to divide her attention between two killers, one whose actions could result in a global pandemic, and the other, an old nemesis whose next target is her fiancée.

Between ruling the night shift in the ER at the Rivers and raising her teenage daughter, Blaise Richelieu has all the drama she needs in her life. When a dashing young attending appears on the scene and relentlessly pursues her, Blaise has plenty of reasons to say no - or at least she tells herself she does, despite Grady’s nearly irresistible charm. Even if Blaise had the slightest desire to play Grady’s game, the past she’s kept hidden from everyone is a secret she intends to keep buried.

Gina Antonelli had big dreams once, of riding her athletic achievements all the way to West Point and being the first in a long family line of soldiers to serve as an officer. When that dream died along with the girl she'd planned to marry one day, she'd vowed to forget about happily ever afters. When Gina agrees to renovate Carrie's soon-to-be new house as a favor to her brother's boss, she doesn't welcome Carrie's overtures at friendship or her own unexpected attraction.