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In a momentous period of British history, Donald Thomas' latest Sherlock Holmes adventure pits the great detective and his faithful biographer, Dr. John Watson, against an international conspiracy led by a disgraced English officer. Colonel Hunter Moran bears upon him the "Mark of the Beast"; his satanic ingenuity leaves a spectacular trail of devastation. It runs from the annihilation of a British armored column by Zulu tribesmen - armed only with shields and spears - to a life-and-death struggle on the sinking passenger steamer Comtesse de Flandre.

It is 1884, and when a fellow landlady finds her lodger poisoned, Mrs. Hudson turns to Sherlock Holmes. The police suspect the landlady of murder, but Mrs. Hudson insists that her friend is innocent. Upon investigating, the companions discover that the lodger, a civil servant recently returned from India, was living in almost complete seclusion, and that his last act was to scrawl a mysterious message on a scrap of paper. The riddles pile up as aged big game hunter Allan Quatermain is spotted at the scene of the crime when Holmes and Watson investigate.

Holmes and Watson discover that the missing woman—Hannah Woolfson—was herself on the trail of a missing person, her close friend Sophia. Sophia was recruited to a group known as the Elysians, a quasi-religious sect obsessed with Ancient Greek myths and rituals, run by the charismatic Sir Philip Buchanan. Hannah has joined the Elysians under an assumed name, convinced that her friend has been murdered. Holmes agrees that she should continue as his agent within the secretive yet seemingly harmless cult, yet Watson is convinced Hannah is in terrible danger.