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Newly minted chief resident at Boston Memorial Hospital Noah Rothauser is swamped in his new position, from managing the surgical schedules to dealing with the fallouts from patient deaths. Known for its medical advances, the famed teaching hospital has fitted several ORs as "hybrid operating rooms of the future" - an improvement that seems positive until an anesthesia error during a routine procedure results in the death of an otherwise healthy man.

Seventeen-year-old Hope Long's life revolves around her brother Jeremy. So when Jeremy is accused of killing the town's beloved baseball coach, Hope's world begins to unravel. Everyone is convinced Jeremy did it, and since he hasn't spoken a word in 9 years, he's unable to defend himself. Their lawyer instructs Hope to convince the jury that Jeremy is insane, but all her life Hope has known that Jeremy's just different than other people - better, even.