Anónimo

A review of the science between the metabolic syndrome, including discussion of obesity, diabetes, hypertension, and hyperlipidemia. We discuss the pathophysiology of how enlargement of adipocytes disrupts metabolic signalling pathways and leads to buildup of lipid intermediates. We then consider how these effects impair health, examining the causes of insulin resistance, atherosclerosis, and dysregulation of blood pressure. We conclude by looking at how such symptoms lead to pathology and increased mortality in overweight and obese individuals. Recommended prelistening is Episode 151: Diet ...

The frontiersmen were a remarkable breed of men. They were often rough and illiterate, sometimes brutal and vicious, often seeking an escape in the wilderness of mid-America from crimes committed back east. In the beautiful but deadly country which would one day come to be known as West Virginia, Kentucky, Michigan, Ohio, Indiana, and Illinois, more often than not they left their bones to bleach beside forest paths or on the banks of the Ohio River.