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By the mid-15th century, the Byzantine Empire had collapsed and the various Crusades that had taken place in the region had largely disrupted the overland routes of the Silk Road and trade. Compounding the difficulties of trade was the rise of the Ottoman Empire in place of the Byzantines and the outbreak of the Black Death in Europe. This audiobook chronicles the early efforts by the Portuguese that helped initiate the Age of Exploration, and the ramifications the colonization had across the world.

Jamestown is fondly remembered today for being the first permanent English settlement in the colonies, but it was not fondly remembered by those who lived and died there. The English quickly learned it would be difficult to establish a permanent settlement because of the poor weather, the swampy terrain, the hostile natives living nearby, and the general inexperience and ineptitude of the English settlers.