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A paradigm-shifting work that revolutionizes our understanding of the origins and structure of science.

Nearly six hundred years ago, a short, genial, cannily alert man in his late 30s took a very old manuscript off a library shelf, saw with excitement what he had discovered, and ordered that it be copied. That book was the last surviving manuscript of an ancient Roman philosophical epic by Lucretius—a beautiful poem containing the most dangerous ideas: that the universe functioned without the aid of gods, that religious fear was damaging to human life, and that matter was made up of very small particles.

Where did the ideas come from that became the cornerstone of American democracy? Not only the erudite Thomas Jefferson, the wily and elusive Ben Franklin, and the underappreciated Thomas Paine, but also Ethan Allen, the hero of the Green Mountain Boys, and Thomas Young, the forgotten Founder who kicked off the Boston Tea Party. These radicals who founded America set their sights on a revolution of the mind. Derided as "infidels" and "atheists" in their own time, they wanted to liberate us not just from one king but from the tyranny of supernatural religion.