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Dr. Emory Charbonneau, a pediatrician and marathon runner, disappears on a mountain road in North Carolina. By the time her husband Jeff, miffed over a recent argument, reports her missing, the trail has grown cold. Literally. Fog and ice encapsulate the mountainous wilderness and paralyze the search for her. While police suspect Jeff of "instant divorce," Emory, suffering from an unexplained head injury, regains consciousness and finds herself the captive of a man whose violent past is so dark that he won't even tell her his name.

Visiting her family's South Carolina estate, socialite Gray Godfrey wakes from a night out to an empty bed. Her husband, Paul, is gone, and a thrashing hangover has wiped her memory clean. At first, she's relieved for the break from her tumultuous marriage; perhaps Paul just needed some space. But when his car is found abandoned on the highway, Gray must face the truth: Paul is gone. And Gray may not want him found. Her life is unraveling. When a stranger named Annie calls claiming to know Paul's whereabouts, Gray reluctantly accepts her help.

On a sunny August morning in 1935, 13-year-old Sophia Gray finds her friend Rosemary wandering in the woods. Rosemary’s yellow dress is tattered and her eyes are vacant and glassy. She beckons to Sophia, desperate to show her something. In an abandoned cabin, beneath a tattered blanket, Sophia discovers Rosemary’s body. It was not Rosemary who led her there, but Rosemary’s ghost. Twenty years later, Sophia finds herself trapped in the sprawling Northern Michigan Asylum for the Insane, in the hands of a malevolent doctor who preys on patients who exhibit paranormal abilities.