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At the end of the Second World War, Cyril Conroy combines luck and a single canny investment to begin an enormous real estate empire, propelling his family from poverty to enormous wealth. His first order of business is to buy the Dutch House, a lavish estate in the suburbs outside of Philadelphia. Meant as a surprise for his wife, the house sets in motion the undoing of everyone he loves. The story is told by Cyril’s son Danny, as he and his older sister, the brilliantly acerbic and self-assured Maeve, are exiled from the house where they grew up by their stepmother.

Chief of Police Ed Kapenash is about to retire. Blond Sharon is going through a divorce. But when a 22-million-dollar summer home is purchased by the mysterious Richardsons—how did they make their money, exactly?—Ed, Sharon, and everyone in the community are swept up in high drama. The Richardsons throw lavish parties, flirt with multiple locals, flaunt their wealth with not one but two yachts, and raise impossible hopes of everyone they meet. When their house burns to the ground and their most essential employee goes missing, the entire island is up in arms.

Ten years ago, sisters Olivia and Melanie Greene were on a backcountry hiking trip when their parents were in a fatal car accident. Over the years, they grew apart, each coping with the loss in her own way. Olivia plunged herself into law school, work, and a materialist view of the world - what you see is what you get, and that's all you get. Melanie dropped out of college and developed an online life-coaching business around her cafeteria-style spirituality - a little of this, a little of that, whatever makes you happy.

From his position behind the pulpit, Reverend Peter Taylor has a unique view of his affluent congregants. By and large, they appear respectable and morally upstanding, but they have their share of troubles - and perhaps even more than their share of sins. Liza Howard is a notorious Jezebel who seduces young and old alike, and who now has her sights set on Judy Bennett’s son, despite his engagement. Meanwhile, Judy hides her own family secrets behind her relentless judgment of others.

In the fall of 1918, 13-year-old German immigrant Pia Lange longs to be far from Philadelphia's overcrowded streets and slums, and from the anti-German sentiment that compelled her father to enlist in the US Army, hoping to prove his loyalty. But an even more urgent threat has arrived. Spanish influenza is spreading through the city. Soon, dead and dying are everywhere. With no food at home, Pia must venture out in search of supplies, leaving her infant twin brothers alone....