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Marie-Laure lives with her father in Paris near the Museum of Natural History, where he works as the master of its thousands of locks. When she is six, Marie-Laure goes blind and her father builds a perfect miniature of their neighborhood so she can memorize it by touch and navigate her way home. When she is 12, the Nazis occupy Paris and father and daughter flee to the walled citadel of Saint-Malo, where Marie-Laure’s reclusive great-uncle lives in a tall house by the sea. With them they carry what might be the museum’s most valuable and dangerous jewel.

In Marbella, Spain, Dr. Kate Warner awakens to a horrifying reality: the human race stands on the brink of extinction. A pandemic unlike any before it has swept the globe. Nearly a billion people are dead--and those the Atlantis Plague doesn't kill, it transforms at the genetic level. A few rapidly evolve. The remainder devolve. As the world slips into chaos, radical solutions emerge. Industrialized nations offer a miracle drug, Orchid, which they mass produce and distribute to refugee camps around the world. But Orchid is merely a way to buy time. It treats the symptoms of the plague but never actually cures the disease.

When Thomas wakes up in the lift, the only thing he can remember is his name. He's surrounded by strangers - boys whose memories are also gone. Outside the towering stone walls that surround them is a limitless, ever-changing maze. It's the only way out - and no one's ever made it through alive. Then a girl arrives. The first girl ever. And the message she delivers is terrifying: Remember. Survive. Run.

The underground mine fires ravaging Pennsylvania coal country have forced 11-year-old Brigid Howley and her family to seek refuge with her estranged grandparents, the formidable Gram and the black lung-stricken Gramp. Tragedy is no stranger to the Howleys, a proud Irish-American clan who takes strange pleasure in the "curse" laid upon them generations earlier by a priest who ran afoul of the Molly Maguires. The weight of this legacy rests heavily on a new generation, when Brigid, already struggling to keep her family together, makes a grisly discovery in a long-abandoned bootleg mine shaft.