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In an instant, millions of people have vanished from Earth. Those left behind scramble to find the cause of this massive disappearance. In their desperation, they fall under the spell of Nicolae Carpathia, a charismatic leader, who vows to bring all religions, governments, and economic systems together. But underneath his promise to unite the world lurks a force of great evil. Can a group of four men and women, who call themselves Tribulation Force, find the strength to topple this wicked foe?

As the youngest bureau chief and head of the Chicago Police Department's Major Case Squad, Boone Drake seems to have it all under control. Only those closest to him know that just a few short years ago, he lost everything that mattered to him in a tragic accident. After years of healing, his life is back on track. He recently married a wonderful woman named Haeley, adopted her son, bought a beautiful home, and rediscovered his faith. But Boone can't fight the feeling that something is about to go terribly wrong...again.

Detective Boone Drake has just masterminded the most massive sting in Chicago history, bringing down the heads of not only the biggest street gangs in the city but also the old crime syndicate. The story is the biggest in decades, and the Chicago Police Department must protect the key witness at all costs. Despite top secret plans to transfer the witness ahead of his testimony before the grand jury, an attempt is made on his life.