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It happens everywhere: offices, schools, even your own backyard. And, seemingly, anything can trigger it: cell phones, sirens, bad music, constant distractions, your boss, or even your spouse. We all know certain things get under our skin. Can science explain why? NPR's Joe Palca and Flora Lichtman take you on a scientific quest through psychology, evolutionary biology, anthropology, and other disciplines to uncover the truth about being annoyed.

Pete Earley had no idea. He'd been a journalist for over 30 years, and the author of several award-winning, even best-selling, nonfiction books about crime and punishment and society. Yet he'd always been on the outside looking in. He had no idea what it was like to be on the inside looking out until his son, Mike, was declared mentally ill, and Earley was thrown headlong into the maze of contradictions, disparities, and catch-22s that is America's mental health system.